October/November 2007 (vol. 04/3)

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Research Plus

Occupational exposure to HIV and use of PEP

A literature review of occupational exposure to HIV reveals a general lack of direct evidence on the use of post-exposure prophylaxis (PEP) drugs following exposure. There have been no randomised controlled trials and the only published evidence is a small-scale retrospective study from the US. There is supportive evidence from animal studies – albeit with a different virus – the use of antivirals to prevent mother-to-baby transmission and PEP following sexual exposure. Animal studies (limited evidence) support early administration of PEP and 28-day regimens. Many healthcare workers remain ignorant about the correct use of PEP.

Occupational Medicine 2007; 57: 329–336.


Occupational Health at Work October/November 2007 (vol. 04/3) pp40