December/January 2007/2008 (vol. 04/4)

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Research Plus

Glomerulonephritis – new evidence on solvent risk

Solvent exposure has been associated with the progression of primary glomerulonephritis to end-stage renal disease (ESRD). A retrospective cohort study followed 269 patients with non-end-stage primary glomerulonephritis confirmed by biopsy. Occupational exposure and other factors were established using a validated interview questionnaire. Aromatic hydrocarbons (toluene and xylene), mixtures of aromatic and aliphatic hydrocarbons, ketones and possibly methylene chloride were associated with the highest risks. Inks, cleaning or degreasing agents and petroleum products were implicated. Interventions to promote screening for proteinuria in solvent-exposed workers and discontinuation of exposure in those with early stage glomerulonephritis may prevent or slow the progression to ESRD.

Occupational and Environmental Medicine 2007; 64: 843–848.


Occupational Health at Work December/January 2007/2008 (vol. 04/4) pp38